What it is
Autologous serum tears are eye drops made from a person's own blood. The liquid part of the blood (serum) is separated and then diluted, so the drops are personalized to the individual who provided the blood.
They are compounded by a pharmacy that prepares them for a specific patient. Autologous serum tears are not an FDA-approved drug. Compounded preparations are handled differently from commercially manufactured, FDA-approved eye drops.
Because they are made from your own blood, they are not something you can simply pick up off a shelf. Availability, preparation methods and the pharmacies involved can differ, which is why a provider's guidance matters.
How it’s traditionally been approached
People with dry, irritated eyes have traditionally started with simpler, widely available approaches, such as over-the-counter artificial tears, environmental adjustments and other options discussed with an eye doctor.
When those approaches haven't felt like enough, some eye doctors discuss other options, which may include compounded drops such as autologous serum tears. Whether any option is appropriate is a decision for a licensed clinician after an evaluation.
Some people also hear about amniotic-derived eye drops or serums. Most of these are also not FDA-approved as drugs, and some amniotic membrane devices are regulated as human tissue products, which is a different pathway. These are separate from autologous serum tears and should not be confused with them.
How the right eye doctor may help
The right eye doctor may help by first understanding what's behind your symptoms. A dry eye evaluation often involves talking through your history and symptoms, and examining the surface of your eyes. Nothing here is a promise of any particular outcome.
If a provider thinks autologous serum tears could be worth considering, they can explain how and where they are prepared, such as which pharmacy is involved and how the blood draw and handling work. They can also tell you whether other options make more sense first.
Questions worth asking: Is this appropriate for me? Which pharmacy prepares it, and how is it processed and stored? What is its FDA or regulatory status? What is the total cost, and is any of it covered by insurance? What should I watch for, and when should I follow up?
The whole-person view
Eyes don't exist apart from the rest of you. Sleep, screen time, stress, overall health and mood can all affect how your eyes feel, and ongoing discomfort can in turn wear on your patience and well-being.
If long-term discomfort is adding to stress or worry, body-based support such as Somatic Experiences may be one way some people explore how they carry tension. Talk therapy through Therapists.plus is another option for those who want support. Both can sit alongside, not replace, care from your eye doctor.
Keep in mind
- Autologous serum tears are pharmacy-compounded from your own blood and are not an FDA-approved drug; only a licensed eye doctor can decide if they are appropriate after an evaluation.
- Most amniotic-derived eye drops and serums are also not FDA-approved as drugs, and they should not be described as stem-cell treatments. Ask any provider about a product's source, processing, regulatory status and total cost.
- Eye pain, sudden vision changes, or injury need prompt professional care. For emergencies call 911; in a crisis call or text 988.
- This page is educational only and is not medical advice, a diagnosis or a treatment plan.
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Frequently asked questions
Where can I get autologous serum tears?
Autologous serum tears are generally obtained through a licensed eye doctor who evaluates you and, if appropriate, works with a compounding pharmacy. They are not sold over the counter. Ask your eye doctor whether they are an option for you and how they are prepared.
Do I need a prescription for autologous serum tears?
Yes, they generally require a clinician's involvement, since they are prepared by a pharmacy for an individual patient. A licensed eye doctor decides whether they are appropriate after an evaluation. Practices and requirements can vary, so ask your provider.
Are autologous serum tears FDA-approved?
No, autologous serum tears are not an FDA-approved drug. They are compounded by a pharmacy from the patient's own blood. Ask your eye doctor how this affects your situation.
Can I make autologous serum tears at home?
No, they should not be made at home. They are prepared by a pharmacy under specific handling conditions, and a licensed eye doctor should guide whether they are appropriate for you.
What kind of doctor should I see for dry eye treatment?
An eye doctor, such as an ophthalmologist or optometrist, is a good starting point for dry eye treatment questions. They can evaluate your eyes and discuss which options, if any, may suit you. Some practices have a particular focus on dry eye.
What should I ask about cost and coverage?
Ask the provider and the pharmacy for the total expected cost, including the blood draw, preparation and any follow-up visits. Also ask your insurance plan whether any part is covered, since this can differ. Get the details in writing before you begin.
Educational resource. Placenta-Derived Eye Serum shares general information and connects people with independent eye doctors. It is not medical advice, diagnosis or treatment. Talk with a licensed professional about your health.